The pharmacognosy of Humulus lupulus L. (hops) with an emphasis on estrogenic properties

Inhibitors of nitric oxide production from hops (Humulus lupulus L.).

Nitric oxide (NO) plays an important role in many inflammatory responses and is also involved in carcinogenesis. In the present study, we investigated the inhibitory effect of extracts from Humulus lupulus L. on both the production of NO and the expression of inducible NO synthase (iNOS) in mouse macrophage RAW 264.7 cells. The production of NO was induced by a combination of lipopolysaccharide...

Anti-proliferative and apoptosis-inducing properties of Xanthohumol, a prenylated chalcone from hops (Humulus lupulus L.)

Xanthohumol (XN)* is a prenylated chalcone found at high concentrations in hop cones (Humulus lupulus L.). XN has been characterized as a promising cancer chemopreventive lead structure that acts via a broad spectrum of bioactivities. This chapter summarizes the anti-proliferative and apoptosis-inducing potential of XN and gives a detailed overview of underlying mechanisms and pathways targeted...

Assessment report on Humulus lupulus L., flos

New prenylchalcones from the hops of Humulus lupulus.

Two new prenylchalcones, xanthohumol C and D, together with two known prenylchalcone derivatives, xanthohumol (1) and 5''-(2''-hydroxyisopropyl)-dihydrofurano-[2'',3''-b]-4,4'-dihydroxy-6'-methoxy-chalcone (4) were isolated and identified from the hops of Humulus lupulus L. The structures of xanhohumol C and D were elucidated as 5''-hydroxy-6'',6''-dimethyl-dihydropyrano-[2'',3''-b]-4,4'-dihydr...

Anti-inflammatory acylphloroglucinol derivatives from Hops (Humulus lupulus).

The polyphenol-enriched fraction of an ethanolic hops extract (Humulus lupulus) was separated to provide four acylphloroglucinol-glucopyranosides (1-4). 1-(2-Methylpropanoyl)phloroglucinol-glucopyranoside 1 has been isolated from hops before, whereas 1-(2-methylbutyryl)phloroglucinol-glucopyranoside 2, known as multifidol glucoside, and 1-(3-methylbutyryl)phloroglucinol-glucopyranoside 3 were f...